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ey0020.3-12 | Translational Highlights | ESPEYB20

3.12. Impaired bone strength and bone microstructure in a novel early-onset osteoporotic rat model with a clinically relevant PLS3 mutation

J Hu , B Zhou , X Lin , Q Zhang , F Guan , L Sun , J Liu , O Wang , Y Jiang , WB Xia , X Xing , M Li

In Brief: The study established a novel rat model with a clinically relevant PLS3 mutation, which replicates the osteoporotic phenotype of early-onset PLS3-related osteoporosis. The findings suggest that treatment with alendronate or teriparatide improves bone mass and microarchitecture, suggesting their potential as effective treatments for early-onset osteoporosis caused by PLS3 mutations.Commentary: This study is an essentia...

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ESPE Yearbook of Paediatric Endocrinology

3.12. Impaired bone strength and bone microstructure in a novel early-onset osteoporotic rat model with a clinically relevant PLS3 mutation

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